McCaffrey’s health anchors SF’s backfield. If he remains at full strength, Guerendo's role is limited; any injury to McCaffrey would inflate Guerendo’s value and push SF to lean on Robinson and depth options.

McCaffrey is the centerpiece, a mismatch nightmare in SF’s attack. Seattle’s run defense shapes his ceiling, but his receiving usage unlocks elite fantasy days when SF leans on him for both ground and air. Expect heavy involvement across rushes and passes.

McCaffrey anchors the opening round, offering elite efficiency and massive weekly floor. The pick balances a potential McCaffrey injury risk with upside that can carry the lineup, especially when paired with his top backup and a versatile receiving corps. Expect him to power multiple weekly ceilings if he stays healthy, making the No. 7 spot justifiable in Primetime settings.

McCaffrey remains a stable, high-floor anchor for San Francisco, leveraging elite involvement in both rushing and receiving to deliver season-long and Week 1 upside.

McCaffrey’s staying power and high upside are underscored as the centerpiece of many rosters, with emphasis on pairing him with older WRs for early-season momentum and balancing age with peak-week upside. His durability and health are framed as key factors that keep him in first-round contention despite surrounding veteran talent.